GrippeEspagneV1, Main, Exploration, bibRecord, 000378

Substitutions in position 222 of haemagglutinin of pandemic influenza A (H1N1) 2009 viruses in Spain.

Identifieur interne : 000378 ( Main/Exploration ); précédent : 000377; suivant : 000379

Substitutions in position 222 of haemagglutinin of pandemic influenza A (H1N1) 2009 viruses in Spain.

Auteurs : Juan Ledesma [Espagne] ; Francisco Pozo ; Mercedes Pérez Ruiz ; Jose María Navarro ; Luis Pi Eiro ; Milagros Montes ; Sonia Pérez Castro ; Jonathan Suárez Fernández ; Juan García Costa ; Mirian Fernández ; Juan Carlos Galán ; María Teresa Cuevas ; Inmaculada Casas ; Pilar Pérez Bre A

Source :

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology [ 1873-5967 ] ; 2011.

RBID : pubmed:21353628

Descripteurs français

KwdFr :
- Adolescent (MeSH), Adulte (MeSH), Adulte d'âge moyen (MeSH), Analyse de séquence d'ADN (MeSH), Antiviraux (usage thérapeutique), Espagne (épidémiologie), Femelle (MeSH), Glycoprotéine hémagglutinine du virus influenza (génétique), Grippe humaine (traitement médicamenteux), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains (MeSH), Mutation (MeSH), Mâle (MeSH), Oséltamivir (usage thérapeutique), Pandémies (MeSH), Sous-type H1N1 du virus de la grippe A (génétique), Sous-type H1N1 du virus de la grippe A (pathogénicité), Substitution d'acide aminé (MeSH).
MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sous-type H1N1 du virus de la grippe A.
- pathogénicité : Sous-type H1N1 du virus de la grippe A.
- traitement médicamenteux : Grippe humaine.
- usage thérapeutique : Antiviraux, Oséltamivir.
- virologie : Grippe humaine.
- épidémiologie : Espagne, Grippe humaine.
- Adolescent, Adulte, Adulte d'âge moyen, Analyse de séquence d'ADN, Femelle, Humains, Mutation, Mâle, Pandémies, Substitution d'acide aminé.
Wicri :
- geographic : Espagne.

English descriptors

KwdEn :
- Adolescent (MeSH), Adult (MeSH), Amino Acid Substitution (MeSH), Antiviral Agents (therapeutic use), Female (MeSH), Hemagglutinin Glycoproteins, Influenza Virus (genetics), Humans (MeSH), Influenza A Virus, H1N1 Subtype (genetics), Influenza A Virus, H1N1 Subtype (pathogenicity), Influenza, Human (drug therapy), Influenza, Human (epidemiology), Influenza, Human (virology), Male (MeSH), Middle Aged (MeSH), Mutation (MeSH), Oseltamivir (therapeutic use), Pandemics (MeSH), Sequence Analysis, DNA (MeSH), Spain (epidemiology).
MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus.
- chemical , therapeutic use : Antiviral Agents, Oseltamivir.
- geographic , epidemiology : Spain.
- drug therapy : Influenza, Human.
- epidemiology : Influenza, Human.
- genetics : Influenza A Virus, H1N1 Subtype.
- pathogenicity : Influenza A Virus, H1N1 Subtype.
- virology : Influenza, Human.
- Adolescent, Adult, Amino Acid Substitution, Female, Humans, Male, Middle Aged, Mutation, Pandemics, Sequence Analysis, DNA.

Abstract

BACKGROUND

A change of aspartic acid (D) to glycine (G) at position 222 in the haemagglutinin (HA) protein of pandemic influenza A (H1N1) 2009 viruses was described in Norway on November 2009 with considerable frequency in fatal and severe cases. This change was detected in other countries and was related only with severe disease. Other substitutions to glutamic acid (E) or asparagine (N) at position 222 were detected among pandemic viruses but it is unclear what implications might have in terms of severity.

OBJECTIVES

To analyse the appearance of amino acid substitutions at position 222 in the HA protein of circulating viruses in Spain and to determine their relationships with the disease symptoms observed.

STUDY DESIGN

Pandemic influenza A (H1N1) 2009 viruses detected in respiratory samples of 273 severe and 533 non-severe cases from different Spanish regions were selected for sequencing of a partial segment of HA1 subunit and studied to monitor substitutions at position 222.

RESULTS

D222G substitution was only detected in viruses from 14 severe cases (5.12%). D222E was found in viruses from 47 severe (17.21%) and from 52 non-severe cases (9.75%). D222N occurred in viruses from 3 additional severe cases (0.37%).

CONCLUSION

Appearance of D222G and D222E substitution in HA of pandemic influenza A (H1N1) viruses circulating in Spain might be related with severe respiratory disease.

DOI: 10.1016/j.jcv.2011.01.020
PubMed: 21353628

Affiliations:

Links toward previous steps (curation, corpus...)

to stream Main, to step Corpus: 00394
to stream Main, to step Curation: 000394

Le document en format XML

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<term>Antiviral Agents (therapeutic use)</term>
<term>Female (MeSH)</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term>
<term>Humans (MeSH)</term>
<term>Influenza A Virus, H1N1 Subtype (genetics)</term>
<term>Influenza A Virus, H1N1 Subtype (pathogenicity)</term>
<term>Influenza, Human (drug therapy)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (virology)</term>
<term>Male (MeSH)</term>
<term>Middle Aged (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Oseltamivir (therapeutic use)</term>
<term>Pandemics (MeSH)</term>
<term>Sequence Analysis, DNA (MeSH)</term>
<term>Spain (epidemiology)</term>
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<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent (MeSH)</term>
<term>Adulte (MeSH)</term>
<term>Adulte d'âge moyen (MeSH)</term>
<term>Analyse de séquence d'ADN (MeSH)</term>
<term>Antiviraux (usage thérapeutique)</term>
<term>Espagne (épidémiologie)</term>
<term>Femelle (MeSH)</term>
<term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term>
<term>Grippe humaine (traitement médicamenteux)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains (MeSH)</term>
<term>Mutation (MeSH)</term>
<term>Mâle (MeSH)</term>
<term>Oséltamivir (usage thérapeutique)</term>
<term>Pandémies (MeSH)</term>
<term>Sous-type H1N1 du virus de la grippe A (génétique)</term>
<term>Sous-type H1N1 du virus de la grippe A (pathogénicité)</term>
<term>Substitution d'acide aminé (MeSH)</term>
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</keywords>
<keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Antiviral Agents</term>
<term>Oseltamivir</term>
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<term>Sous-type H1N1 du virus de la grippe A</term>
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<keywords scheme="MESH" qualifier="usage thérapeutique" xml:lang="fr"><term>Antiviraux</term>
<term>Oséltamivir</term>
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<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Amino Acid Substitution</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Mutation</term>
<term>Pandemics</term>
<term>Sequence Analysis, DNA</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Analyse de séquence d'ADN</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mutation</term>
<term>Mâle</term>
<term>Pandémies</term>
<term>Substitution d'acide aminé</term>
</keywords>
<keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Espagne</term>
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<front><div type="abstract" xml:lang="en"><p><b>BACKGROUND</b>
</p>
<p>A change of aspartic acid (D) to glycine (G) at position 222 in the haemagglutinin (HA) protein of pandemic influenza A (H1N1) 2009 viruses was described in Norway on November 2009 with considerable frequency in fatal and severe cases. This change was detected in other countries and was related only with severe disease. Other substitutions to glutamic acid (E) or asparagine (N) at position 222 were detected among pandemic viruses but it is unclear what implications might have in terms of severity.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>OBJECTIVES</b>
</p>
<p>To analyse the appearance of amino acid substitutions at position 222 in the HA protein of circulating viruses in Spain and to determine their relationships with the disease symptoms observed.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>STUDY DESIGN</b>
</p>
<p>Pandemic influenza A (H1N1) 2009 viruses detected in respiratory samples of 273 severe and 533 non-severe cases from different Spanish regions were selected for sequencing of a partial segment of HA1 subunit and studied to monitor substitutions at position 222.</p>
</div>
<div type="abstract" xml:lang="en"><p><b>RESULTS</b>
</p>
<p>D222G substitution was only detected in viruses from 14 severe cases (5.12%). D222E was found in viruses from 47 severe (17.21%) and from 52 non-severe cases (9.75%). D222N occurred in viruses from 3 additional severe cases (0.37%).</p>
</div>
<div type="abstract" xml:lang="en"><p><b>CONCLUSION</b>
</p>
<p>Appearance of D222G and D222E substitution in HA of pandemic influenza A (H1N1) viruses circulating in Spain might be related with severe respiratory disease.</p>
</div>
</front>
</TEI>
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<Month>08</Month>
<Day>15</Day>
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<Month>11</Month>
<Day>21</Day>
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<Title>Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology</Title>
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<ArticleTitle>Substitutions in position 222 of haemagglutinin of pandemic influenza A (H1N1) 2009 viruses in Spain.</ArticleTitle>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">A change of aspartic acid (D) to glycine (G) at position 222 in the haemagglutinin (HA) protein of pandemic influenza A (H1N1) 2009 viruses was described in Norway on November 2009 with considerable frequency in fatal and severe cases. This change was detected in other countries and was related only with severe disease. Other substitutions to glutamic acid (E) or asparagine (N) at position 222 were detected among pandemic viruses but it is unclear what implications might have in terms of severity.</AbstractText>
<AbstractText Label="OBJECTIVES" NlmCategory="OBJECTIVE">To analyse the appearance of amino acid substitutions at position 222 in the HA protein of circulating viruses in Spain and to determine their relationships with the disease symptoms observed.</AbstractText>
<AbstractText Label="STUDY DESIGN" NlmCategory="METHODS">Pandemic influenza A (H1N1) 2009 viruses detected in respiratory samples of 273 severe and 533 non-severe cases from different Spanish regions were selected for sequencing of a partial segment of HA1 subunit and studied to monitor substitutions at position 222.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">D222G substitution was only detected in viruses from 14 severe cases (5.12%). D222E was found in viruses from 47 severe (17.21%) and from 52 non-severe cases (9.75%). D222N occurred in viruses from 3 additional severe cases (0.37%).</AbstractText>
<AbstractText Label="CONCLUSION" NlmCategory="CONCLUSIONS">Appearance of D222G and D222E substitution in HA of pandemic influenza A (H1N1) viruses circulating in Spain might be related with severe respiratory disease.</AbstractText>
<CopyrightInformation>Copyright © 2011 Elsevier B.V. All rights reserved.</CopyrightInformation>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Ledesma</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
<AffiliationInfo><Affiliation>Centro Nacional de Gripe-Madrid, Instituto de Salud Carlos III, Madrid, Spain. jledesmam@isciii.es</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>Pozo</LastName>
<ForeName>Francisco</ForeName>
<Initials>F</Initials>
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<Author ValidYN="Y"><LastName>Pérez Ruiz</LastName>
<ForeName>Mercedes</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Navarro</LastName>
<ForeName>Jose María</ForeName>
<Initials>JM</Initials>
</Author>
<Author ValidYN="Y"><LastName>Piñeiro</LastName>
<ForeName>Luis</ForeName>
<Initials>L</Initials>
</Author>
<Author ValidYN="Y"><LastName>Montes</LastName>
<ForeName>Milagros</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pérez Castro</LastName>
<ForeName>Sonia</ForeName>
<Initials>S</Initials>
</Author>
<Author ValidYN="Y"><LastName>Suárez Fernández</LastName>
<ForeName>Jonathan</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>García Costa</LastName>
<ForeName>Juan</ForeName>
<Initials>J</Initials>
</Author>
<Author ValidYN="Y"><LastName>Fernández</LastName>
<ForeName>Mirian</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Galán</LastName>
<ForeName>Juan Carlos</ForeName>
<Initials>JC</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cuevas</LastName>
<ForeName>María Teresa</ForeName>
<Initials>MT</Initials>
</Author>
<Author ValidYN="Y"><LastName>Casas</LastName>
<ForeName>Inmaculada</ForeName>
<Initials>I</Initials>
</Author>
<Author ValidYN="Y"><LastName>Pérez Breña</LastName>
<ForeName>Pilar</ForeName>
<Initials>P</Initials>
</Author>
<Author ValidYN="Y"><CollectiveName>Spanish Influenza Surveillance System (SISS)</CollectiveName>
</Author>
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<Month>02</Month>
<Day>24</Day>
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<MeshHeading><DescriptorName UI="D019943" MajorTopicYN="N">Amino Acid Substitution</DescriptorName>
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Substitutions in position 222 of haemagglutinin of pandemic influenza A (H1N1) 2009 viruses in Spain.

Substitutions in position 222 of haemagglutinin of pandemic influenza A (H1N1) 2009 viruses in Spain.

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